S. 545
119th Congress
Combating Illicit Xylazine Act
35
Cosponsors
5
Actions
0
Amendments
1
Committees
—
Since introduced
Placed on Senate Legislative Calendar under General Orders. Calendar No. 372.
15 April 2026·3 months ago
Summary
Reported to Senate · Updated 10 July 2026
Combating Illicit Xylazine Act
This bill regulates xylazine under the Controlled Substances Act (CSA).
Xylazine, also known as tranq, is a nonopioid sedative and pain reliever that is approved for use in animals. Recently, the Drug Enforcement Administration (DEA) has reported an increase in trafficking of fentanyl mixed with xylazine.
This bill adds xylazine, including its salts, isomers, and salts of isomers, to schedule III of the CSA. Schedule III controlled substances, including anabolic steroids, buprenorphine, and ketamine, have less potential for abuse than a schedule I or II substance, have a currently accepted medical use, and have low or moderate risk of dependence if abused.
Under the bill, manufacturing, distributing, or dispensing xylazine, or possessing with intent to manufacture, distribute, or dispense xylazine for illicit use is subject to criminal penalties under the CSA. The bill also requires xylazine transactions to be tracked in the drug reporting system maintained by the DEA.
The bill exempts from registration under the CSA persons and entities that possess xylazine (1) lawfully dispensed by a veterinarian or pharmacy and (2) for an animal or for use in certain animal-control or wildlife programs.
The bill also exempts xylazine manufacturers from the CSA's physical security requirements.
Finally, the bill requires the DEA, in coordination with the Department of Health and Human Services (HHS), to provide Congress with a report on how the agencies previously determined whether xylazine should be a controlled substance, including the full text of HHS's recommendations to the DEA for scheduling xylazine.
Timeline
5 actions
Placed on Senate Legislative Calendar under General Orders. Calendar No. 372.
15 April 2026 · Calendars
Committee on the Judiciary. Reported by Senator Grassley with an amendment in the nature of a substitute. Without written report.
15 April 2026 · Committee
Committee on the Judiciary. Ordered to be reported with an amendment in the nature of a substitute favorably.
26 March 2026 · Committee
Read twice and referred to the Committee on the Judiciary.
12 February 2025 · IntroReferral
Introduced in Senate
12 February 2025 · IntroReferral
Sponsorship
35 cosponsors
Sponsor
Democrat:Sen. Cortez Masto, Catherine [D-NV]NVCosponsors
- Democrat1543%
- Republican1954%
- Independent13%
- Democrat:Sen. Merkley, Jeff [D-OR]OR
- Republican:Sen. Cruz, Ted [R-TX]TX
- Democrat:Sen. Durbin, Richard J. [D-IL]IL
- Republican:Sen. Cornyn, John [R-TX]TX
- Republican:Sen. Blackburn, Marsha [R-TN]TN
- Republican:Sen. Moody, Ashley [R-FL]FL
- Republican:Sen. Lankford, James [R-OK]OK
- Republican:Sen. McCormick, David [R-PA]PA
- Republican:Sen. Crapo, Mike [R-ID]ID
- Republican:Sen. Justice, James C. [R-WV]WV
- Independent:Sen. King, Angus S., Jr. [I-ME]ME
- Republican:Sen. Budd, Ted [R-NC]NC
- Republican:Sen. Lummis, Cynthia M. [R-WY]WY
- Democrat:Sen. Bennet, Michael F. [D-CO]CO
- Democrat:Sen. Fetterman, John [D-PA]PA
- Republican:Sen. Tillis, Thomas [R-NC]NC
- Democrat:Sen. Gallego, Ruben [D-AZ]AZ
- Democrat:Sen. Shaheen, Jeanne [D-NH]NH
- Republican:Sen. Britt, Katie Boyd [R-AL]AL
- Republican:Sen. Capito, Shelley Moore [R-WV]WV
- Republican:Sen. Scott, Rick [R-FL]FL
- Republican:Sen. Wicker, Roger F. [R-MS]MS
- Republican:Sen. Risch, James E. [R-ID]ID
- Democrat:Sen. Hassan, Margaret Wood [D-NH]NH
- Democrat:Sen. Kelly, Mark [D-AZ]AZ
- Democrat:Sen. Klobuchar, Amy [D-MN]MN
- Democrat:Sen. Kaine, Tim [D-VA]VA
- Democrat:Sen. Gillibrand, Kirsten E. [D-NY]NY
- Democrat:Sen. Rosen, Jacky [D-NV]NV
- Democrat:Sen. Blumenthal, Richard [D-CT]CT
- Republican:Sen. Grassley, Chuck [R-IA]IA
- Democrat:Sen. Cantwell, Maria [D-WA]WA
- Democrat:Sen. Luján, Ben Ray [D-NM]NM
- Republican:Sen. Hyde-Smith, Cindy [R-MS]MS
- Republican:Sen. Young, Todd [R-IN]IN
Classification
Policy area
Crime and Law EnforcementLegislative subjects
Committees
1
Judiciary Committee
Senate · Standing
- Referred To12 Feb 2025
- Referred To12 Feb 2025
- Markup By26 Mar 2026
Cosponsor momentum
Cumulative over time
Cosponsors grew from 18 on 12 February 2025 to 35 on 9 June 2026.
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